Detalhe da pesquisa
1.
Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework.
Drug Metab Dispos
; 50(7): 957-967, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35504655
2.
Multistate models of developmental toxicity: Application to valproic acid-induced malformations in the zebrafish embryo.
Toxicol Appl Pharmacol
; 414: 115424, 2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33524444
3.
A Bayesian population physiologically based pharmacokinetic absorption modeling approach to support generic drug development: application to bupropion hydrochloride oral dosage forms.
J Pharmacokinet Pharmacodyn
; 48(6): 893-908, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34553275
4.
Well-tempered MCMC simulations for population pharmacokinetic models.
J Pharmacokinet Pharmacodyn
; 47(6): 543-559, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32737765
5.
Prediction of maternal and foetal exposures to perfluoroalkyl compounds in a Spanish birth cohort using toxicokinetic modelling.
Toxicol Appl Pharmacol
; 379: 114640, 2019 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31251942
6.
Population pharmacokinetic reanalysis of a Diazepam PBPK model: a comparison of Stan and GNU MCSim.
J Pharmacokinet Pharmacodyn
; 46(2): 173-192, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30949914
7.
Adverse outcome pathways: opportunities, limitations and open questions.
Arch Toxicol
; 91(11): 3477-3505, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-29051992
8.
Joint modeling of survival and longitudinal non-survival data: current methods and issues. Report of the DIA Bayesian joint modeling working group.
Stat Med
; 34(14): 2181-95, 2015 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24634327
9.
Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors.
Environ Health Perspect
; 132(3): 37005, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38498338
10.
Low-dose metabolism of benzene in humans: science and obfuscation.
Carcinogenesis
; 34(1): 2-9, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23222815
11.
Understanding Discordance between In Vitro Dissolution, Local Gut and Systemic Bioequivalence of Budesonide in Healthy and Crohn's Disease Patients through PBPK Modeling.
Pharmaceutics
; 15(9)2023 Aug 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37765205
12.
Zonation related function and ubiquitination regulation in human hepatocellular carcinoma cells in dynamic vs. static culture conditions.
BMC Genomics
; 13: 54, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22296956
13.
Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury.
Toxicol Appl Pharmacol
; 259(3): 270-80, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22230336
14.
PBPK Modeling to Simulate the Fate of Compounds in Living Organisms.
Methods Mol Biol
; 2425: 29-56, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35188627
15.
SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator.
Front Pharmacol
; 13: 929200, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36091744
16.
A quantitative AOP of mitochondrial toxicity based on data from three cell lines.
Toxicol In Vitro
; 81: 105345, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35278637
17.
Population PBPK modeling using parametric and nonparametric methods of the Simcyp Simulator, and Bayesian samplers.
CPT Pharmacometrics Syst Pharmacol
; 11(6): 755-765, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35385609
18.
Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks.
ALTEX
; 39(3): 499518, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35258090
19.
Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.
Arch Toxicol
; 85(5): 367-485, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21533817
20.
Opening a debate on open-source modeling tools: Pouring fuel on fire versus extinguishing the flare of a healthy debate.
CPT Pharmacometrics Syst Pharmacol
; 10(5): 420-427, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33793084